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Pregame analysis and predictions of the Pittsburgh Pirates vs. Chicago Cubs MLB game to be played on June 15, 2025 on ESPN.

Andrew McCutchen, the second batter of the game, homered to give the Bucs a 1-0 lead early. It was McCutchen’s 32nd career homer against the Cubs, which ties him for second-most among active players with Paul Goldschmidt. Eugenio Suárez leads with 36.

Mike Burrows held the Chicago Cubs to one run in 5.1 innings but the Pittsburgh Pirates’ offense was stifled in a 2-1 loss at Wrigley Field on Saturday afternoon.

Pirates ace Paul Skenes struck out five in five scoreless innings. Skenes was matched by Cade Horton, who permitted three hits in 5 2/3 shutout innings.

The Pittsburgh Pirates changed their lineup ahead of their next game vs. the Chicago Cubs, who bring in a left-handed pitcher. Cubs will have left-handed pitcher Matthew Boyd make the start vs. the Pirates at Wrigley Field,

The Pittsburgh Pirates defeated the Chicago Cubs 2-1 in 10 innings on Friday afternoon at Wrigley Field. Paul Skenes took a no-decision after throwing 5.0-shutout innings and Isiah Kiner-Falefa drove in the game-winning run on a sac fly in the top of the 10th.

Rookie Cade Horton matched Pittsburgh Pirates ace Paul Skenes in a pitchers’ duel Friday, but the Chicago Cubs lost 2-1 in 10 innings.