The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The San Francisco 49ers suffered two key injuries to their offensive backfield during their 35-10 "Sunday Night Football" loss to the Buffalo Bills in Week 13. Early in the contest, starting ...

Here's everything you need to know about the 49ers' current RB depth chart following injuries to McCaffrey and Mason. Rookie Isaac Guerendo will assume the starting role for the 49ers come Sunday's ...

While the 49ers may rotate in other RBs more than they would have with a player higher on the depth chart starting, chances ...

RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17’s game vs. the Lions ...

49ers still unsure if rookie RB can play vs. Rams after foot injury This article originally appeared on Niners Wire: 49ers RB depth chart is a mess after another injury Recommended Stories ...

Being prepared for what life throws at him is a specialty for 49ers running back Patrick Taylor Jr., whether it’s the ...

The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday against ...

Here’s a look at the 49ers’ running back depth chart against the Rams with a trio of players out. Guerendo, a fourth-round pick out of Louisville, played well in place of McCaffrey and Mason ...