The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction.

Conformational changes within myosin lead to its movement relative to an actin filament. Several crystal structures exist for myosin bound to various nucleotides, but none with bound actin.

Several recent publications have demonstrated the importance of nuclear actin and nuclear myosin I in transcription. Here we review these publications and their implications. In addition, we ...

Myosin in muscles behaves in a unique way, which might explain why muscles have such strong contractile power. A cartoon showing the asymmetry in the weak binding between myosin and actin that biases ...

The research, which has direct implications for how root systems manage responses to plant hormones, also has broader implications for understanding the condensation of other motile proteins that move ...

Experimental myosin inhibitor MT-125 sensitizes glioblastoma to radiation and kinase inhibitors, prolonging survival in mouse models.

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

To further validate their findings, the researchers treated wild-type plants with chemical inhibitors that block myosin XI or disrupt the actin cytoskeleton along which it moves.

Myosin-5 working stroke and walking on F-actin. ... Even so, the freezing has to be done with millisecond accuracy to capture the myosin in the act of priming (pre-powerstroke).

The novel cardiac myosin inhibitor aficamten improved peak oxygen uptake in symptomatic obstructive hypertrophic cardiomyopathy (HCM), the pivotal SEQUOIA-HCM trial showed. At 24 weeks, the mean ...