An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have ...

To achieve this, non-muscle myosin 2 forms higher-order filaments within the cell, which then interact with the actin cytoskeleton network to apply force and produce movement. Until recently ...

Furthermore, cofilin, which promotes actin turnover, and myosin, which interacts with actin, were crucial for vesicle fusion.

View Full Profile. Learn about our Editorial Policies. A.S. Smith et al., “Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability ...

Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and ... We are also investigating actin filament ...