in patients with the rare liver disease Alagille syndrome (ALGS). Kayfanda (odevixibat) is labelled in the EU to treat cholestatic pruritus – itching caused by impaired bile formation or flow ...
We have reported a mouse model for Alagille syndrome (ALGS), a multisystem disorder, which predominantly affects bile duct development and is mostly caused by haploinsufficiency of the Notch pathway ...
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