Medscape16d
Mechanisms of Disease: The Kidney-specific Chloride Channels ClCKA and ClCKB, the Barttin Subunit, and Their Clinical Relevance
A severe salt-losing tubulopathy (Bartter syndrome type III) develops if ClCKB is nonfunctional, whereas a common genetic variant of the CLCNKB gene that leads to increased activity of ClCKB ...