While alkylating agents can be highly effective in disrupting cancer cell growth, these drugs also pose a potential risk. They can harm the cells in bone marrow, which produces red blood cells. In ...

In fact, reactions of alkylating agents with nucleosomal DNA typically mirror those seen with naked DNA, showing very similar sequence preferences and only modestly (2- to 3-fold) decreased adduct ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues. Researchers from the Wellcome Sanger Institute, the University of Cambridge, ...

Alkylating agents do this by attaching to the cell’s DNA and stopping the cells from multiplying. The drugs target rapidly dividing cancer cells, slow down cell growth, and kill them in a ...

Researchers have uncovered new patterns of DNA damage associated with specific chemotherapy drugs to guide cancer treatment for less effects.

Chemotherapeutic DNA alkylating agents are common weapons employed to fight both pediatric and adult cancers. In addition to cancerous cells, nontarget tissues are subjected to the cytotoxicity of ...

Alkylating agents damage DNA in cancer cells, but they may also affect bone marrow cells, which can cause leukemia. The risk of developing leukemia is small, but it increases with larger doses of ...

The sensor can detect DNA-alkylating agents, a class that includes cisplatin, and oxidizing agents such as hydrogen peroxide and hydroxyl radicals. Using the sensors, researchers can monitor ...

To design the alkylating agent, chemistry professor Steven E. Rokita and postdoctoral associate Qibing Zhou (now assistant professor of organic chemistry at Virginia Commonwealth University ...

1. Alkylating Agents. These drugs interfere with the DNA inside cells, preventing them from multiplying. DNA is the genetic material in cells that guides their growth and function.

DNA repair can be divided into a set of mechanisms that identify and correct damage in DNA molecules. ... The damage caused by alkylating agents reacting with DNA can also be repaired through ...

MMS is a DNA alkylating agent mechanistically similar to several agents commonly used in cancer chemotherapy. Alkylating agents “are known to induce replication stress, potentially mimicking the ...