Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

Chemotherapeutic alkylating agents induce a range of cytotoxic and mutagenic adducts onto DNA. Alkylating agent-induced damage to DNA is sensed and repaired by different cellular mechanisms ...

The alkylating agent-induced t-AML model predicts that DNA double-strand break repair is directly affected by loss of functional DNA MMR (Casorelli et al., 2003).

While alkylating agents can be highly effective in disrupting cancer cell growth, these drugs also pose a potential risk. They can harm the cells in bone marrow, which produces red blood cells. In ...

Alkylating agents do this by attaching to the cell’s DNA and stopping the cells from multiplying. The drugs target rapidly dividing cancer cells, slow down cell growth, and kill them in a ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues. Researchers from the Wellcome Sanger Institute, the University of Cambridge, ...

Alkylating agents damage DNA in cancer cells, but they may also affect bone marrow cells, which can cause leukemia. The risk of developing leukemia is small, but it increases with larger doses of ...

The sensor can detect DNA-alkylating agents, a class that includes cisplatin, and oxidizing agents such as hydrogen peroxide and hydroxyl radicals. Using the sensors, researchers can monitor ...

To design the alkylating agent, chemistry professor Steven E. Rokita and postdoctoral associate Qibing Zhou (now assistant professor of organic chemistry at Virginia Commonwealth University ...

Tucked within its double-helix structure, DNA contains the chemical blueprint that guides all the processes that take place within the cell and are essential for life. Therefore, repairing damage ...

1. Alkylating Agents. These drugs interfere with the DNA inside cells, preventing them from multiplying. DNA is the genetic material in cells that guides their growth and function.

MMS is a DNA alkylating agent mechanistically similar to several agents commonly used in cancer chemotherapy. Alkylating agents “are known to induce replication stress, potentially mimicking the ...