Sweet Home Alabama follows an aspiring fashion designer after she leaves New York City to go home and divorce. ... playing Dr. Derek Shepherd, a.k.a. "McDreamy" on Grey’s Anatomy (2005 to 2021 ...

Sweet Home Alabama became a classic rom-com almost as soon as it hit theaters in 2002, ... playing Dr. Derek "McDreamy" Shepherd on Grey's Anatomy until 2015.