Researchers at Dana-Farber Cancer Institute collaborated with multiple institutions to pinpoint rare germline structural ...

Cancer is primarily a genetic disease that is clonal in nature. It usually starts when a single cell acquires a series ... can be passed on through the germ line (i.e., inherited from one's ...

A new paper in Genome Biology and Evolution finds that the link between paternal age and rare congenital disorders is more complex than scientists had previously thought.

The most commonly identified germline pathogenic mutations were CHEK2, ATM/BRCA2 and MITF in the clear cell RCC group, and FH and CHEK2 in the non-clear cell RCC group. Compared to the non cancer ...

a hereditary disorder," says Sohail Tavazoie, the Leon Hess Professor at Rockefeller. "We have been so focused on the cancer cells, the 'seeds', that we've ignored the germline -- 'the soil'.

Metastasis we believe is, at least in part, a hereditary disorder. We have been so focused on the cancer cells, the 'seeds', that we've ignored the germline-;'the soil'. It's now clear that ...

The nucleus of a germline stem cell undergoes two divisions, firstly separating homologous chromosomes and secondly separating chromatids. Haploid gametes contain 23 single chromosomes.

Marengo Therapeutics, Inc., a clinical-stage biotechnology company pioneering novel approaches for precision T cell activation, today announced that Zhen Su, M.D., MBA, the Company's Chief Executive ...