When an HIV virion prepares to enter a T cell, it undergoes some shape-shifting changes. These take place on the virus's so-called envelope protein, the protein on the surface of the virus that ...

The resulting complex of viral cDNA and virion proteins, now referred to as the pre-integration complex (PIC), is transported to the nucleus (Fig. 1). Figure 1: Models of flap-dependent HIV ...

Third, Nef enhances virion infectivity and viral replication 112. This effect is mediated by Nef present in HIV virions and is due, at least in part, to the ability of Nef to induce actin ...

HIV-1 Gag directs virion formation and budding from host cell membranes by interacting with critical membrane microdomains. At least 253 cellular proteins from multiple cellular pathways have been ...

Dr. Ochsenbauer-Jambor investigates the role of DC-SIGN in the capture and trans-infection of HIV-1 with special emphasis on virion internalization pathways and the acquisition of selective ...