Heparin use itself can result in decreased antithrombin activity, an effect that is seen primarily with unfractionated heparin and not with low-molecular-weight heparin. 23 Among patients ...

Antithrombin, the principal physiological inhibitor of the blood coagulation proteinase thrombin, requires heparin as a cofactor. We report the crystal structure of the rate-determining encounter ...

Heparin interacts with the naturally occurring plasma protein, Antithrombin III, to induce a conformational change, which markedly enhances the serine protease activity of Antithrombin III ...

Unfractionated vs. low-molecular-weight heparin (LMWH): Find out what the difference is and how they work for DVT. ... Both UFH and LMWH do this by activating antithrombin.

Heparin increases the anticoagulant activity of antithrombin and thus may decrease its levels by 30%, which may lead to erroneous diagnosis of antithrombin deficiency. Because of the reduced levels or ...

For MATRIX Antithrombin, the investigators randomized 7,213 patients with STEMI (55.6%) or NSTE-ACS (44.4%) slated for PCI between October 2011 and November 2014 to receive either bivalirudin (n = ...

Dr. Rao added that “from this paper, it appears that switching from heparin to bivalirudin in the primary PCI setting is quite safe and preserves the mortality benefit of bivalirudin. . . . So, ...

Causes of heparin resistance. Our main hypothesis was that, although rare, the heparin resistance could be secondary to an acquired antithrombin deficiency in the setting of severe sepsis,2 as ...

In these women, the decision to give or withhold heparin in the ... Assays for factor V Leiden, 18 the prothrombin G20210A mutation, 19 protein C, 20 protein S, 21 antithrombin, 22 anticardiolipin ...

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