Details of the U-M study will be published in the Aug. 15 issue of Science. It is the first published paper linking Hirschsprung's disease to functional defects in neural crest stem cells, or NCSCs.

We recently found that the colonic epithelium of both aganglionic and ganglionic segments are altered both in patients with Hirschsprung disease and in Endothelin receptor B knockout (Ednrb ...

Hirschsprung's disease is a birth defect that affects about 1 in 5,000 babies in the U.S., according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD).

Dr. Rollins: Hirschsprung disease is a disorder where the nerve cells of the rectum and/or part of the colon don't form normally, and these nerve cells are responsible for relaxation of the rectum and ...

Gfra1 under-expression causes Hirschsprung’s disease and associated enterocolitis in mice. Cellular and Molecular Gastroenterology and Hepatology, 2018; DOI: 10.1016/j.jcmgh.2018.12.007 ...

Hirschsprung’s work paved the way for others describing similar cases, but it took until the mid 1900s before the causes of the disease became more clear.

Hirschsprung’s work paved the way for others describing similar cases, but it took until the mid 1900s before the causes of the disease became more clear. A breakthrough in our understanding of ...

Hirschsprung's disease is a congenital disorder caused by the absence of ganglion cells in the colon, which causes problems with passing stool. Hirschsprung's disease is often treated with surgery ...

At present the only certain method for the diagnosis of Hirschsprung's disease is deep-muscle biopsy of the rectum to prove the absence of ganglion cells in Auerbach's myenteric plexus. 1–4 ...

Hirschsprung's disease is a congenital disorder caused by the absence of ganglion cells in the colon, which causes problems with passing stool. Hirschsprung's disease is often treated with surgery ...

Hirschsprung's disease occurs when the nerves that should be found in the muscles of the colon are partially or completely missing. Without those nerves, the colon can't move stool through the ...