However, PyScript acts as a wrapper, allowing you to embed Python code directly between py-script tags and have it automatically executed by Pyodide.

Beyond cProfile for Python profiling cProfile is hardly the only way to profile a Python application. cProfile is certainly one of the most convenient ways, given that it’s bundled with Python.

If you can find a way to speed up the implementation of that loop — say, by using Python built-ins instead of handwritten code — you could get a measurable performance improvement.