Patrick Dempsey revealed that he is often recognized more for 'Can't Buy Me Love' than for 'Grey's Anatomy,' despite the 20 years between the two.

Patrick Dempsey is the proudest papa in the world as his twin sons make a momentous big step in their futures: high school graduation! And in the rare photo, we see which twin looks like which ...

Patrick "McDreamy" Dempsey credits his acting career for helping him prepare for his return to racing. Fans can follow that journey in a new documentary.

Patrick Dempsey reveals why he will not be reprising the role of Mark Kincaid in Scream 7 despite speculation that he was Sidney Prescott's husband.

People's newest "Sexiest Man Alive" revealed Tuesday that his family "laughed quite hard" after the "Grey's Anatomy" star told them the news.

NPR's Leila Fadel talks with actor Patrick Dempsey about his efforts to raise money for cancer treatment and prevention.

Things were not so McDreamy on the set of "Grey's Anatomy" before Patrick Dempsey's stunning exit, according to a new book.

Patrick Dempsey opens up in an exclusive interview with PEOPLE about his mom Amanda Dempsey's cancer diagnosis. He saw firsthand the impact the disease can have on families. The actor's mother was ...

Former "Grey's Anatomy" star Patrick Dempsey says the long-running medical drama has "inspired" so many people to go into the medical profession.

Patrick Dempsey is teasing that he might be involved in Scream 7 and will reprise his role in the slasher film.

Investigators say evidence found at the crime scene decades ago matched the DNA of James Patrick Dempsey.

Patrick Dempsey wanted to return for 'Scream 7,' but now he explains why it didn't happen.