Patrick Dempsey ’s role as McDreamy — a.k.a. Dr. Derek Shepherd — on Grey’s Anatomy might be his most iconic, but it’s not always the one he’s recognized for the most.

The next year, at age 21, he began taking on bigger and better roles. Here are some of the most notable Patrick Dempsey movies and TV shows. In The Mood (1987) ...

Patrick Dempsey (Grey’s Anatomy) has joined the cast of Paramount+ with Showtime’s Dexter: Original Sin in a series regular role. In the Dexter prequel series, Dempsey will play Aaron Spencer ...

PEOPLE's Sexiest Man Alive has always been dreamy. See throwback photos of a young Patrick Dempsey when he was just starting to steal hearts in the '80s and '90s ...

Patrick and Jillian Dempsey are celebrating a sweet milestone. On Wednesday, the "Ferrari" actor and beauty entrepreneur each took to Instagram to share loving messages to each other for their ...

People's newest "Sexiest Man Alive" revealed Tuesday that his family "laughed quite hard" after the "Grey's Anatomy" star told them the news.

Patrick Dempsey is said to be fuming after his former Grey's Anatomy co-star Ellen Pompeo complained about their initial pay disparity on the ABC drama.

Patrick Dempsey has been cast in a regular role in Dexter prequel series, Original Sin. The Grey's Anatomy star is set to play Aaron Spencer, the Captain of the Miami Metro Homicide department who ...

Patrick Dempsey has joined the ‘Dexter’ prequel series ‘Original Sin,’ where he will play a character integral to the backstory of Christian Slater’s Harry Morgan ...

Patrick Dempsey’s role as McDreamy — a.k.a. Dr. Derek Shepherd — on Grey’s Anatomy might be his most iconic, but it’s not always the one he’s recognized for the most. In a Dec. 4 interview with Parade ...