People's newest "Sexiest Man Alive" revealed Tuesday that his family "laughed quite hard" after the "Grey's Anatomy" star told them the news.

Winning People's Sexiest Man Alive didn't score Patrick Dempsey points with his family. In fact, they had the opposite reaction to the news.

In an exclusive conversation with PEOPLE, the actor, 58, speaks candidly about his mom Amanda Dempsey 's cancer diagnosis and how it impacted his entire family.

Former Grey's Anatomy star Patrick Dempsey's new Fox hitman thriller series, 'Memory of a Killer,' has added another TV icon to its expanding cast.

Patrick Dempsey posted a rare family photo, celebrating his twin sons’ graduation from high school. His sons, Darby and Sullivan, attended Crossroads high school in Los Angeles.

Hollywood heartthrob Patrick Dempsey made a rare public appearance with his wife Jillian and their daughter Talula, stepping ...

Patrick and Jillian Dempsey shared sweet notes to each other on Wednesday for their 25th wedding anniversary.

Patrick Dempsey has played a love interest in a number of films and television shows, but in his personal life, he tied the knot with Jillian Fink in 1999. Over the years, the pair admitted to ...

Patrick Dempsey is a proud dad to three children, including twins, with wife Jillian Fink. Inside the 'Grey's Anatomy' alum's family life and parenthood.

In recent years, the entire family of five attended the Los Angeles premiere of “Ferrari” in December 2023, which starred Patrick Dempsey as Piero Taruffi.

Patrick Dempsey says his eyes were opened when his mom was diagnosed with cancer. In an exclusive conversation with PEOPLE, the actor, 58, speaks candidly about his mom Amanda Dempsey's cancer ...

Patrick Dempsey says his eyes were opened when his mom was diagnosed with cancer. In an exclusive conversation with PEOPLE, the actor, 58, speaks candidly about his mom Amanda Dempsey's cancer ...