Granulomas are cellular aggregates that are the pathologic hallmarks of tuberculosis. These chronic inflammatory lesions have long been considered to be necessary for containment of infection. A ...

One of the main challenges for tuberculosis (TB) therapy is how to deliver drugs to the site of disease. Once the body’s immune system is infected with tuberculosis, it forms granulomas—tight ...

For 70 years, clinicians thought they knew the shape of tuberculosis granulomas in the lungs of patients. Histology — the study of microscopic structures in thin slices of lung tissue in the ...

Scientists used computers to model the formation of tuberculosis granulomas in the lung -- the non-active (latent) form of infection found in 2 billion individuals worldwide (11 million in the U.S ...

The tuberculosis granulomas showed marked heterogeneity in shape, volume and number in the lung sections. (See link to study below for videos of the three-dimensional views.) ...

Rethinking TB. New observations of the early stages of tuberculosis infection may turn scientists' understanding of the bug's pathogenesis on its head: clumps of immune cells, called granulomas, long ...

This creates “caves” that trap Mycobacterium tuberculosis, known as granulomas. “[Granulomas] change over time, but they’re independent. So the environment that the bacteria are in in one granuloma ...

“TB is still difficult to treat and kills nearly 1.5M people a year. Our work finds striking similarities between granulomas and the tumor microenvironment suggesting that immune evasion in ...

Despite the immune evasion/modulation response strategies that M. tuberculosis can induce, the initial response to infection is virtually always a strong inflammatory response. This is because the ...

Granuloma structure and distribution of the antibiotic BTZ-043 in differently stained tissue sections of two tuberculosis granulomas. The stains show (in z-shaped order from top left to bottom right): ...

The team located TB granulomas in macaque monkeys’ lungs using a state-of-the-art imaging technique that allowed them to scan the lungs of live animals in real time and track development of ...