Before going over their fundamental differences, let's address the main question. Yes, Python can do virtually everything Excel can. But it’s not an apples-to-apples comparison.

While Excel offers many formatting options to make your workbook visually appealing, manually formatting large datasets can be incredibly tedious. But Python can automate it with ease.

Python integration in Excel won’t require additional software or add-ons and is instead part of Excel’s built-in connectors and Power Query.

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