The Greater Cincinnati Northern Kentucky Stroke Study—a population-based epidemiological study—found that between 1993/1994 and 2005, the mean age of those who have a stroke declined by 2 years, while ...

Appendix 1. Author Relationships With Industry and Other Entities (Relevant) e53 Appendix 2. Reviewer Relationships With Industry and Other Entities (Comprehensive) e55 When developing recommendations ...

In this investigation 52 547 patients with a new atrial fibrillation diagnosis between 2010 and 2020 were retrospectively identified. We applied a type of artificial intelligence called tabular ...

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. During atherogenesis, vascular smooth muscle (VSM) cells migrate to populate ...

The development of pulmonary hypertension (PH) is common and has adverse prognostic implications in patients with heart failure due to left heart disease (LHD), and thus far, there are no known ...

Background— The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique opportunities for basic and ...

Statins are powerful lipid-lowering drugs that inhibit cholesterol biosynthesis via downregulation of hydroxymethylglutaryl coenzyme-A reductase. 1 They are largely used in patients with or at risk of ...

Resistant hypertension is defined as failure to achieve goal blood pressure (BP) <140/90 mm Hg (or <130/80 mm Hg in patients with diabetes mellitus or chronic kidney disease) in patients with ...

Rationale:Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse ...

Measurement of blood pressure (BP) in the upright posture is recommended by all hypertension guidelines to detect orthostatic hypotension especially in elderly patients. 1 However, a number of studies ...

The Editors of Circulation: Cardiovascular Quality and Outcomes are pleased to announce a new Patient or Caregiver Viewpoint section in the Journal. Viewpoints will be authored by patients or their ...

Background—MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular ...