We propose the warped linear mixed model (WarpedLMM), a principled generalization of the standard LMM that allows to fit phenotype transformations while performing genetic analyses.

An algorithm for linear mixed models substantially reduces memory usage and run time for genome-wide association studies. The improved algorithm scales linearly in cohort size, allowing the ...

Then we describe three common applications of the linear mixed model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability ...

Just as PROC GLM is the flagship procedure for fixed-effect linear models, the MIXED procedure is the flagship procedure for random- and mixed-effect linear models. PROC MIXED fits a variety of mixed ...

The methodology will be illustrated for linear mixed models in the analysis of 22-dimensional, highly unbalanced, longitudinal profiles of hearing thresholds. Biometrics is a scientific journal ...