The Detroit Lions take on the Buffalo Bills at Ford Field Sunday in what many are calling a possible Super Bowl preview.

The Detroit Lions lost for the first time since Sept. 15 in a high-scoring affair with the Buffalo Bills in Week 15 at Ford Field in Detroit in a matchup of two of the NFL's best teams. The Lions (12-1) fell into an early two-touchdown hole and could not ...

DETROIT – The Detroit Lions snapped an 11-game winning streak Sunday, falling to the Buffalo Bills in a high-scoring shootout that saw the Lions twice attempt an onside kick.

The Bills improved to 11-3, two games behind the Kansas City Chiefs in the AFC with three games remaining, and took a one-game lead over Pittsburgh for the conference’s second seed.

Loss number two is in the books for the Detroit Lions. Their tilt with the Buffalo Bills was expected to be a high-scoring affair, and a 48-42 score line certainly lived up to it. Unfortunately, Detroit was not on the right side of this one,

The Buffalo Bills (10-3) take on the Detroit Lions (12-1) Sunday in Week 15. Kickoff from Ford Field is set for 4:25 p.m. ET (CBS). Below, we look at Bills vs. Lions odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Sunday's Lions-Bills game at Ford Field.

Winning 11 straight games in the NFL — the Detroit Lions’ current streak — is pretty rare. But winning 12 straight, as the Lions could do on Sunday with a victory over the Buffalo Bills at Ford Field (4:25 p.m., CBS)? That’s elite territory ...

The Detroit Lions have won 11 straight games and can set a franchise single-season record for victories with a win Sunday over the Buffalo Bills.

Here’s the preview, odds, best bets, and expert predictions for the upcoming Buffalo Bills vs. Detroit Lions game.

The Detroit Lions are tied for the best record in the NFC, but can earn the No. 1 seed and a first-round bye by winning their final 3 games.