Experimental myosin inhibitor MT-125 sensitizes glioblastoma to radiation and kinase inhibitors, prolonging survival in mouse models.

Myosin II, like many molecular motors, is a two-headed dimer held together by a coiled-coil rod. The stability of the (S2) rod has implications for head−head interactions, force generation, and ...

Myosin II molecules assemble and form filaments through their C-terminal rod region, and the dynamic filament assembly−disassembly process of nonmuscle myosin II molecules is important for cellular ...

Background and aims: Chronic idiopathic intestinal pseudo-obstruction (CIIP) is a severe motility disorder associated with significant morbidity. Several histopathological (neuropathic and myopathic) ...