In TEMPO-3, adding tavapadon to levodopa resulted in an increase of 1.1 hours in ‘on’ time – 1.7 hours versus 0.6 hours with placebo – after 27 weeks, accompanied by a significant ...

Management Adjustment of dopaminergic therapy (carbidopa–levodopa and entacapone) to minimize motor fluctuations and camptocormia. ... the mechanism of pathogenesis remains unclear.

AbbVie has launched its Produodopa for Parkinson’s in the EU, becoming the first and only 24-hour levodopa-based subcutaneous infusion therapy for the disease.

Carbidopa–levodopa was discontinued. Psychiatry was consulted, and a monthlong cross-taper to discontinue olanzapine and initiate aripiprazole with a target dosage of 20 mg daily was recommended.

In this context, STN-DBS might partially share a similar mechanism with GPi-DBS. However, it is yet to be elucidated how the capability of DBS to suppress 'transmission failure' leads to the ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

To further investigate the mechanism of quenching for monomer crowders and polymeric dextran 40, a temperature variation study was carried out using 10 μM Trp and 300 mg/mL crowders by varying the ...

Background: One of the core clinical features of dementia with Lewy bodies (DLB) is extrapyramidal syndrome (EPS). Levodopa is currently the gold standard oral therapy for Parkinson’s disease (PD), ...

Parkinson's disease is a chronic and disabling illness. There is still some uncertainty in its diagnosis, particularly in the early stages, as some other neurological conditions present with similar ...

COMT = catechol-O-methyltransferase, LCIG = levodopa/carbidopa intestinal gel, LECIG = levodopa/entacapone/carbidopa intestinal gel, MAO-B = monoamine oxidase B. An OFF period is a period of limited ...

Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...