Heparin-induced thrombocytopenia develops ... activation and the release of procoagulant-rich microparticles. 18,20 Platelet and monocyte microparticles activate the coagulation cascade by ...

However, prescription medications are quite common. Patients can receive anticoagulants, such as heparin, ... production and ...

Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which ...

The coagulation cascade is regulated by natural anticoagulants, ... Heparin-induced thrombocytopenia is an adverse drug reaction mediated by the immune system, ...

These particles, called nanoscale self-titrating therapeutics (nanoSTATs), release the anticoagulant heparin in response to the activity of thrombin, a key enzyme in the blood coagulation cascade ...

The systemic use of heparin for treating severe ... demonstrated that SARS-CoV-2 instigates a 'cytokine storm' that ultimately results in the activation of the coagulation cascade, ...

Activation of the coagulation cascade mediated by increases in the expression of tissue factor, thrombin and fibrinogen, and decreases in the expression of TFPI, AT-III, heparin cofactor II ...

Heparin plays a key role in allergic and ... that belongs to the blood coagulation system. The study thus provides an unexpected link between the clotting cascade and mast cell-driven pro ...

Heparin, when complexed with antithrombin III, ... since clot-bound thrombin retains its enzymatic activity and can continue to stimulate the coagulation cascade. ...

Severe COVID-19 patients have sustained platelet activation, likely contributing to thrombotic issues seen with the infection. Antiplatelet therapy such as aspirin may be of benefit, researchers say.