Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

The alkylating agent-induced t-AML model predicts that DNA double-strand break repair is directly affected by loss of functional DNA MMR (Casorelli et al., 2003).

In fact, reactions of alkylating agents with nucleosomal DNA typically mirror those seen with naked DNA, showing very similar sequence preferences and only modestly (2- to 3-fold) decreased adduct ...

While alkylating agents can be highly effective in disrupting cancer cell growth, these drugs also pose a potential risk. They can harm the cells in bone marrow, which produces red blood cells. In ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues. Researchers from the Wellcome Sanger Institute, the University of Cambridge, ...

The sensor can detect DNA-alkylating agents, a class that includes cisplatin, and oxidizing agents such as hydrogen peroxide and hydroxyl radicals. Using the sensors, researchers can monitor ...

Alkylating agents do this by attaching to the cell’s DNA and stopping the cells from multiplying. The drugs target rapidly dividing cancer cells, slow down cell growth, and kill them in a ...

To design the alkylating agent, chemistry professor Steven E. Rokita and postdoctoral associate Qibing Zhou (now assistant professor of organic chemistry at Virginia Commonwealth University ...

It is apparent that uracil mustard is an effective alkylating agent for oral use, administered as a large dose in a few days (0.5 to 0.8 mg. per kilogram of body weight over three days) as ...

1. Alkylating Agents. These drugs interfere with the DNA inside cells, preventing them from multiplying. DNA is the genetic material in cells that guides their growth and function.

MMS is a DNA alkylating agent mechanistically similar to several agents commonly used in cancer chemotherapy. Alkylating agents “are known to induce replication stress, potentially mimicking the ...