For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

Published today (1 July 2025) in Nature Genetics, the researchers show that many but not all chemotherapy agents cause ...

Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

Researchers have uncovered new patterns of DNA damage associated with specific chemotherapy drugs to guide cancer treatment for less effects.

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

As part of Cancer Grand Challenges team Mutographs, the researchers uncovered new patterns of DNA damage, or mutational signatures ... all of the main chemotherapy classes, including alkylating agents ...

Chlorambucil (N,N-bis(2-chloroethyl)-p-aminophenylbutyric acid) is a bifunctional alkylating drug belonging to the nitrogen mustard group and is widely used as an anticancer agent. As the antitumor ...

A method, using HPLC combined with electrospray tandem mass spectrometry (ES-MS/MS), was developed and validated to detect and quantify the major DNA adduct resulting from exposure to the ultimate ...