CP-506 is under clinical development by Convert Pharmaceuticals and currently in Phase II for Triple-Negative Breast Cancer (TNBC).

Bisantrene, for example, was not expected to cluster with the antitubulin agents. Cyanomorpholinodoxorubicin was presumptively classified as a DNA binder, but clusters with the alkylating agents ...

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent oxygenases in histone ...

OBI’s pipeline also includes the first-in-class AKR1C3-targeted small-molecule prodrug OBI-3424, which selectively releases a potent DNA-alkylating antitumor agent in the presence of the aldo-keto ...

Veliparib plus temozolomide did not significantly extend overall survival in patients with newly diagnosed, ...

Forty of 41 patients received prolonged alkylating agent therapy, but severe leukopenia ... with myeloma have a quantitative impairment of DNA and RNA synthesis after mitogenic stimulation.

(c) What are direct downstream Nrf2 effectors? (d) Besides, streptozotocin is also a powerful DNA alkylating agent, are such effects relieved by eugenol? - It is puzzling that all molecular analyses ...

With so many at-home DNA tests now available to consumers, learning more about your ancestry is easier than ever. Plus, these tests make for thoughtful, unique holiday gifts. All you have to do is ...

Centre for Chemical Biology, Department of Chemistry, Institute for Nucleic Acids, University of Sheffield, Brook Hill, Sheffield S3 7HF, U.K. Centre for Chemical Biology, Department of Chemistry, ...

The Chargers have 30 players who are slated to be free agents this offseason. The 2025 New League year begins on March 12 at 1 p.m. (PT), which also marks the official start of free agency. UFA: Any ...