For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

Published today (1 July 2025) in Nature Genetics, the researchers show that many but not all chemotherapy agents cause ...

Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

Researchers have uncovered new patterns of DNA damage associated with specific chemotherapy drugs to guide cancer treatment for less effects.

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

As part of Cancer Grand Challenges team Mutographs, the researchers uncovered new patterns of DNA damage, or mutational signatures ... all of the main chemotherapy classes, including alkylating agents ...

Chlorambucil (N,N-bis(2-chloroethyl)-p-aminophenylbutyric acid) is a bifunctional alkylating drug belonging to the nitrogen mustard group and is widely used as an anticancer agent. As the antitumor ...

These cases highlight significant clinical and radiographic response to the combination of DNA damaging agents with platinum and topoisomerase inhibitor-based therapy as well as second line treatment ...

Two agents (compounds 18 and 19) exhibited mean GI 50 values of 96 nM and 182 nM, respectively, in the NCI human tumor cell line panel. Derivatization of the potent DNA cross-linking agent 15 to an N ...

Thus, with this respect, some specific inhibitors of these enzymes such as paramagnetic divalent metal cations (25Mg2+, 43Ca2+, and 67Zn2+) and the ultrashort single-stranded DNA fragments are ...

Article citations More>> Monzaffari, S.M., Beitollani, N., Bousnenri, A. and Samarian, K. (2024) DNA Repair in Malignacies. Amir Kabir University of Technology. has been cited by the following article ...