Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

Joshua K. Sabari, MD, describes the mechanism of action of lurbinectedin as a synthetic alkaloid that binds to guanine residues in the minor groove of DNA, forming adducts that disrupt DNA repair ...

Alkylating agents do this by attaching to the cell’s DNA and stopping the cells from multiplying. The drugs target rapidly dividing cancer cells, slow down cell growth, and kill them in a ...

Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic ...

Increased sensitivity to DNA-alkylating agents such as mitomycin-C (MMC) or diepoxybutane (DEB) is a “gold standard” test for FA diagnosis.

MMS is a DNA alkylating agent mechanistically similar to several agents commonly used in cancer chemotherapy. Alkylating agents “are known to induce replication stress, potentially mimicking the ...

Side Effects Alkylating agents damage the DNA in cells and can cause serious side effects. Alkylating agents affect the cells in the bone marrow, which work to make new cells. Because of this, a rare ...

The compounds release methylator in a similar manner as temozolomide, an FDA-approved DNA alkylating agent. They induce S-phase and G2/M cell cycle arrest in MCF7 cells and lead to accumulation of ...