Never before in NFL history have two teams with at least 14 wins each gotten together for a regular-season matchup. But that ...

The stage is set for the biggest regular season game in NFL history as the Detroit Lions take on the Minnesota Vikings on ...

The 49ers will wrap up a massively disappointing season without a number of starters when they face the Cardinals in Week 18.

Will the 49ers pull off an upset against the Cardinals? Discover fan and staff predictions for this divisive Week 18 NFC West showdown.

San Francisco 49ers quarterback Brock Purdy exited Monday night's shootout with the Detroit Lions in the final two minutes, as the Niners were driving for a late touchdown to cut the Lions' lead to ...

The Seahawks hit the road for the final time this season as they get set to take on the division rival L.A. Rams in Week 18. Seahawks reporter Jen Mueller breaks down the Seahawks' final game of the ...

This year, Detroit surged to a 12-1 record to start the season and has been one of the top teams in the NFL for months. Both Lions' losses -- a 20-16 setback against Tampa Bay and a 48-42 defeat at ...

Check out the latest injury report for the 49ers, including Deebo Samuel's status ahead of the Week 18 showdown against the Cardinals.

San Francisco 49ers head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, TE George Kittle and others before the team's Week 18 matchup against the Cardinals and shared his vision ...

Nick Khan's prediction becomes a reality on Monday night. The World Wrestling Entertainment executive said during earning ...

Former Pittsburgh Steelers quarterback Josh Dobbs will start for the San Francisco 49ers in their game against the Arizona ...

Darnold signed a one-year deal worth $10 million to join the Vikings ahead of this season. Last week, Spotrac projected his ...