But in about 5% to 10% of cases, the cause is hereditary. This means that the cancer is due to a gene change, called a “mutation,” that’s passed down from a parent. Researchers have ...

It can cause symptoms such as breathing problems and hoarseness. Therapy that targets the mutation, such as EGFR inhibitors, may help. “EGFR” stands for “epidermal growth factor receptor.” ...

These findings set the stage for the current studies, which provide the first molecular pictures of KBTBD4 targeting the CoREST complex through interactions induced by both cancer mutations and a ...

As an intrinsic cellular pathway, nonsense-mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harboring truncating mutations. We developed and conducted a ...

Each patient received ≥ one peptide resulting from a frameshift insertion and deletion. Seven patients received a peptide containing a neoantigen derived from a cancer driver mutation ...

Merck & Co.’s Covid-19 pill is giving rise to new mutations of the virus in some patients, according to a study that underscores the risk of trying to intentionally alter the pathogen’s genetic code.

The CRISPR system is a powerful tool for the introduction of genomic mutations in a variety of organisms including many plant species. Originally adapted from a bacterial pathogen defense system, it ...

We find that mutations in almost all cancer driver genes contain remarkably little information on patient prognosis. However, CNAs in these same driver genes harbor significant prognostic power. Focal ...