In the emergency department, the oral temperature was 36.8°C, the blood pressure 129/71 mm Hg, the heart rate 87 beats per minute, and the oxygen saturation 98% while she was breathing ambient ...

The antithrombotic action of heparin is dependent on antithrombin; in vivo studies have shown that the plasma levels of fibrinopeptide A (a marker of thrombin activity) dramatically decrease after ...

Current Antithrombin Therapies in Patients With ACS Undergoing an Invasive Approach Unfractionated heparin (UFH) was discovered in 1916 by Jay McLean, then a second-year medical student working ...

Bivalirudin has several notable mechanistic advantages compared with unfractionated heparin, including activity against clot-bound thrombin, inhibition of thrombin-induced platelet activation, short ...

Figure 1 ABRs of Qfitlia following prior BPA or CFC prophylaxis were reduced or comparable, respectively (estimated mean ABR for BPA: 3.41 vs 11.29; estimated mean ABR for CFC: 6.93 vs 5.96).10 ...

In the FlowLine Bipore Heparin vascular prosthesis, heparin is attached to the lumen surface of the prosthesis by means of covalent bondings and ionic interactions, a stable and permanent method.

Bivalirudin has several notable mechanistic advantages compared with unfractionated heparin, including activity against clot-bound thrombin, inhibition of thrombin-induced platelet activation ...

According to the report, fitusiran could become the first antithrombin-lowering therapy based on a double-stranded RNA molecule, pending approval, and has a sales prediction of $1 billion.

Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins. A single ...

Figure S1, antithrombin polymerization data at 53 °C, pH 7.4 and at 37 °C, pH 5.7; Figure S2, hydrogen/deuterium-exchange data for a representative set of antithrombin peptides; Figure S3, phenotypic ...