A novel heparinase III from Pedobacter schmidteae (PsHep-III) with high activity and good stability was successfully cloned, expressed, and characterized. PsHep-III displayed the highest specific ...

Scientists have uncovered a stealthy tactic used by the SARS-CoV-2 virus: one of its proteins can leap from infected cells to ...

How one of the oldest components of the human immune system can trigger a mysterious and little-understood syndrome.

Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins. A single ...

"While most organs are thought to be shaped by static, brick-like cells, our study highlights the powerful role of dynamic, migrating cells—and how they work together to sculpt living tissue ...

In prostate and breast cancer cells, removing CD36 blocked the cancer-fighting power of these drugs. This wasn’t just true for PROTACs but for other large drugs too, like doxorubicin and navitoclax.

Abnormal amino acid metabolism supports cancer cell proliferation, invasion, and immune evasion in hepatocellular carcinoma (HCC). Previous research exploring amino acid metabolism in HCC has ...

Researchers have long known that glycosaminoglycan-binding proteins (HBPs) help control vital processes like cell growth, inflammation, and blood clotting. But a recent discovery has revealed a hidden ...

The loss of the Y chromosome in tumour cells is linked to poor outcomes for people with cancer 1, but this genetic alteration might also compromise immune cells that would otherwise fight the ...

Landmark trials using stem cells to treat Parkinson’s disease in the USA and Japan mark a turning point for cell therapy in neurodegeneration. Similar approaches to Alzheimer’s disease and ...

Such an approach “is interesting and powerful,” says Chuck Murry, director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at the University of California ...