In the SHEP trial, treatment of isolated systolic hypertension with chlorthalidone stepped-care therapy for 4.5 years was associated with a longer life expectancy at 22 years of follow-up.

Authors and Disclosures. Daniel Duprez Cardiovascular Division, University of Minnesota, 420 Delaware St SE, MMC 508, Minneapolis, MN 55455, USA Tel.: +1 612 624 4948 Fax: +1 612 626 4411 dupre007 ...