– Mexiletine appears to be safe and is likely an effective treatment for managing symptoms of myotonia (delayed muscle relaxation after a contraction) in people with non-dystrophic myotonia and it ...

The drawback of targeting myosin itself is that physiologically, cardiac myosin is required to perform two contradictory functions. Drugs that directly promote the contractile function of myosin do so ...

In eukaryotic cells, actin filaments and myosin motors self-organize into a diversity of shapes (Blanchoin et al., 2014).A shell-like cortex is ubiquitously found under the cell membrane, which is ...

The role of myosin and actin proteins The most abundant components of our muscles are myosin motor proteins, and bar-like filaments assembled from protein actin. Coordinated ‘crawling’ of myosin motor ...

Coordinated 'crawling' of myosin motor proteins along actin filaments is the principal mechanism that generates the force for muscle contraction. However, such myosin-based force-production is not ...

Research groups at the University of Helsinki uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile ...

When the heart muscle contracts, myosin binds to actin to generate force. Our lab is trying to determine if motion -- and how fast the motion occurs -- makes myosin let go of actin faster and make ...

To test this hypothesis, we used an in vitro actin motility assay to determine myosin sliding velocity, calcium sensitivity, and attachment/detachment kinetics of acetylated/deacetylated ACTA1. In ...

The protein that they use the most is actin, and they use it to sense fast muscle myosin contraction and slow non-muscle myosin contraction. The deformation of different adaptor proteins regulates the ...