This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

In this type of contraction, a protein in your muscles called myosin binds to another protein called actin and drags it to ...

α-SMA, α-smooth muscle actin; ATP, adenosine triphosphate ... pathway in NIH-3T3 myofibroblasts, leading to collagen gel contraction (Prados et al., 2021). These findings underscore the potential of ...

Sevasemten is an orally administered first-in-class fast skeletal myosin inhibitor designed to protect muscle against contraction-induced muscle damage in muscular dystrophies including Becker and ...

This occurs through a physiologic process that leads to an increased number of contractile proteins (actin and myosin) in ...

Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have identified ...

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Background: Sarcopenia, the accelerated loss of muscle mass and function, is commonly associated with aging, especially in older adults. While low serum calcium has been linked to muscle loss in ...