Introduction: Podocytopathies are a uniquely renal disease syndrome, in which direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome ... to clarify the role of autophagy in the ...

The nephrotic syndrome is a disease of unknown etiology characterized by edema, proteinuria, hypoalbuminemia and hypercholesterolemia. It apparently occurs as a result of an antigen–antibody ...

This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting ...

In another example of the effect of modifier genes, Schiefermeier et al [45] tried to delineate why some patients have later-onset neurologic as well as hepatic symptoms by examining the potential ...

Note: Diagnostic testing should meet conditions listed in either column labeled A, B, or C. Diagnostic tests: (A) molecular testing; or (B) slit lamp examination, serum ceruloplasmin (CP), and 24 ...

Huch’s pancreatic organoids are now a promising avenue for disease modeling and generating precision medicines to treat ...

Such studies may likewise lead to a better understanding of the pathogenesis of the pseudosclerotic ... of the concept of this disease or syndrome. One can now visualize a familial defect in ...

Marfan syndrome (MFS) is a heritable multisystemic disorder with a spectrum of clinical manifestations primarily linked to variants in the Fibrillin-1 ...

If the loss of kidney function is severe, proteinuria may be a part of a more serious condition called nephrotic syndrome. This causes fluid buildup and dyslipidemia (unhealthy levels of cholesterol ...

Sometimes referred to as ‘cardiorenal syndrome,’ the definition varies widely, and the overall understanding of pathogenesis is limited. This is probably owing to the lack of precision and ...