Granulomas are cellular aggregates that are the pathologic hallmarks of tuberculosis. These chronic inflammatory lesions have long been considered to be necessary for containment of infection. A ...

One of the main challenges for tuberculosis (TB) therapy is how to deliver drugs to the site of disease. Once the body’s immune system is infected with tuberculosis, it forms granulomas—tight ...

The tuberculosis granulomas showed marked heterogeneity in shape, volume and number in the lung sections. (See link to study below for videos of the three-dimensional views.) ...

For 70 years, clinicians thought they knew the shape of tuberculosis granulomas in the lungs of patients. Histology — the study of microscopic structures in thin slices of lung tissue in the ...

Rethinking TB. New observations of the early stages of tuberculosis infection may turn scientists' understanding of the bug's pathogenesis on its head: clumps of immune cells, called granulomas, long ...

Scientists used computers to model the formation of tuberculosis granulomas in the lung -- the non-active (latent) form of infection found in 2 billion individuals worldwide (11 million in the U.S ...

“TB is still difficult to treat and kills nearly 1.5M people a year. Our work finds striking similarities between granulomas and the tumor microenvironment suggesting that immune evasion in ...

Tuberculosis (TB) remains one of ... The human immune system often creates a barrier around the bacteria, forming what medical professionals call a granuloma.

Granuloma structure and distribution of the antibiotic BTZ-043 in differently stained tissue sections of two tuberculosis granulomas. The stains show (in z-shaped order from top left to bottom right): ...

The team located TB granulomas in macaque monkeys’ lungs using a state-of-the-art imaging technique that allowed them to scan the lungs of live animals in real time and track development of ...