eLife2d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
Saint Albans Messenger2d
‘Doing business in uncertain times:’ Treasurer’s task force talks turbulence in Vermont in light of new federal administration
Pieciak thanked collaborators present: Amy Spear, Chamber of Commerce president; Roxanne Vought, who leads the Vermont ...
eLife3d
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...
pharmaphorum5d
Tris cues up filing for non-opioid pain drug on phase 3 win
Tris Pharma has set its sights on an FDA filing for pipeline drug cebranopadol before the end of this year after the drug achieved significant pain relief in abdominoplasty patients in a late ...
Nature3d
Structure-based drug design articles from across Nature Portfolio
Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...