eLife2d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
Nature3d
Structure-based drug design articles from across Nature Portfolio
Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...
Indiatimes19d
TRIS: The Mother of All Search Engines on India’s Soul and Spirit
The Tuli Research Centre for India Studies has launched an extensive digital archive at www.tuliresearchcentre.org, capturing India's cultural essence through a unique range of artifacts.
eLife3y
Structure of the human ATM kinase and mechanism of Nbs1 binding
In keeping with previous structures of ATM and its yeast homolog Tel1, the dimeric human ATM kinase adopts a symmetric, butterfly-shaped structure. The conformation of the ATM kinase domain is most ...
Investopedia4y
Organizational Chart: Types, Meaning, and How It Works
Investopedia / Yurle Villegas An organizational chart, or org chart, graphically represents an organization's structure by detailing the roles, responsibilities, and relationships between ...