What is lupus, and what does it do to your body? I just had a friend diagnosed with it after many months of tests. -- T.S.B.

A team studied the differences between monogenic and nonmonogenic lupus nephritis and the predictors of end-stage kidney disease. Monogenic lupus nephritis is distinct from non-monogenic disease with ...

Serum S100A8/A9 levels are “significantly higher’ among patients with cognitive impairment in systemic lupus erythematosus, and changes in S100A8/A9 correspond to changes in cognition over 1 year, ...

A 35-year-old man presents with a chief complaint of purple discoloration of his toes and associated skin lesions that have ...

Dysregulation of the alternative complement pathway, hallmarked by isolated reduction of the serum C3 fraction, is now recognized as an additional feature of lupus nephritis. Persistent, isolated low ...

The U.S. Food and Drug Administration has approved GSK's autoinjector of Benlysta (belimumab) for subcutaneous injection in ...

Background Abnormalities of type I interferon signaling and production can initiate lupus development. Disturbances of nucleic acid-sensing molecules triggered autoreactivity in lupus mouse models.

But if you have lupus, your immune system doesn’t clear out the dead cells — and it attacks healthy cells instead. These attacks can lead to photosensitive lupus rashes and increase inflammation ...

In the case of SLE, an expert panel was convened during 2012–2013 in order to develop treat-to-target guidance for this disease as well. [36, 37] Based on a large supervised literature search a ...

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Rash announced his retirement as Beechwood’s head coach in 2023 after 17 years leading the program. Rash won 200 games and eight state championships with the Tigers, including a three-peat in ...

From subtle rashes to sun-safety strategies, Drs Maureen McMahon and John Edminister discuss how to recognize cutaneous lupus and protect patients from UV-triggered flares.