Colorado quarterback Shedeur Sanders finished in the top 10 in the Heisman voting and is arguably the best quarterback in the country and a likely NFL first-round draft pick in 2025. He has completed 74.4% of his passes for 3,936 yards and 35 touchdowns, with just eight interceptions. His quarterback rating is 168.2.

The most notable change in Colorado's starting lineup will come at linebacker, as Nikhai Hill-Green recently transferred to the Alabama Crimson Tide. Head coach Deion Sanders will also likely be without Phillip Houston, who started nine games at right tackle before suffering an injury.