Concentration polarization of ion-exchange membranes in electrodialysis units limits operational current densities to the underlimiting regime, preventing process intensification by simply increasing ...

Keratinases is a special hydrolytic enzyme produced by microorganisms, which has the ability to catalyze the degradation of keratin. Currently, keratinases show great potential for application in many ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp3)–H bonds using N-hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions ...

Macrophages play crucial roles in inflammation, and their dysfunction is a contributing factor to various human diseases. Maintaining the balance of cholesterol and lipid metabolism is central to ...

A synthetic approach to dibenzophospholes was developed via the gold- and copper-catalyzed annulation reactions of arynes and phosphites. The reaction conditions demonstrated a broad functional group ...

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, and material sciences. Although fluorine-nitrogen chemistry has a long and rich history, this field has ...

mRNA therapy holds significant promise for preventing and treating diverse diseases. The development of safe and effective cationic polymers for mRNA delivery is essential for advancing its clinical ...

1,2,4-Thiadiazoles, a significant class of heterocyclic compounds, are widely found in biologically active molecules. Herein, we report a green electrochemical three-component reaction of amines, ...

3-Allylindoles constitute a key structural feature in many natural products and bioactive compounds. In this work, we developed a Mo-mediated reductive cyclization ...

Although the most commonly used method for enhancing a limit of detection (LoD) in immunoassay is adopting chemiluminescence (CL), the liquid form of CL substrates has hindered its use for rapid ...

Synthetic biology has played an important role in the renaissance of natural products research during the post-genomics era. The development and integration of new tools have transformed the workflow ...