BACKGROUND: Desmosomal gene variants (DGVs) have been associated with a diverse spectrum of phenotypic manifestations within ...

Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.). Department of Surgery, Duke ...

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Methods: To develop a comprehensive therapy for MSMDS, we utilized CRISPR-Cas9 adenine base editing to correct the ACTA2 R179H mutation. We generated isogenic human induced pluripotent stem cell (iPSC ...

Cardiac intensive care units are witnessing a demographic shift, characterized by patients with increasingly complex or ...

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China (Y. Zheng, Y.C., W.W., Y.T., C.L., M.Z., Y.S., Y.-g.-s.W ...

Such findings were generally ignored because multiple epidemiological studies have demonstrated reduced cardiovascular disease (CVD) events with increasing levels of physical activity (PA). Randomized ...

Gu et al caution that results in immature hiPSC-CMs may not predict efficacy in mature cardiomyocytes. Although hiPSC-CMs lack some features of mature cardiomyocytes, 3 they share similar molecular ...

The recent study by Bortolin et al, 1 “Antisense Oligonucleotide Therapy for Calmodulinopathy,” presents an innovative therapeutic strategy for rare inherited arrhythmia syndromes. By leveraging ...

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Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types ...

Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Sub-Faculty of Clinical and Molecular Medicine, Victorian Heart ...