Jared Goff and the Detroit Lions visit Levi’s Stadium for the final home game of this injury-riddled 49ers season Click to share on Facebook (Opens in new window) Click to share on Twitter ...

The 49ers are riding a tow game losing streak into Week 17. They are poised to increase it to three in their matchup with the Lions. Here are three reasons why the 49ers will lose to the Lions.

Either way, we’ll likely hear their names often on Monday Night Football, as one of those newcomers will be protecting 49ers’ quarterback Brock Purdy’s blindside against the Lions.

The 49ers will be down another key starter against the Lions on Monday night. All-Pro cornerback Charvarius Ward will not be active when the 49ers take on the Lions. He is out with a "personal ...

The Detroit Lions and San Francisco 49ers have released their final injury reports of the week ahead of their Monday night showdown in Week 17 and there are a total of six players ruled out and ...

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN's Adam Schefter. More news: Titans Reveal RB Tony Pollard's Playing ...

49ers Place Aaron Banks on IR, Activate Tatum Bethune from IR; Other Roster Moves Ahead of #DETvsSF The San Francisco 49ers announced a series of roster moves ahead of their Week 17 matchup ...

The San Francisco 49ers are prepping for Week 17 against the Detroit Lions on Monday Night Football. What they're not prepping for is a playoff push in January. At 6-9, Kyle Shanahan and the 49ers ...

Heading into a matchup against the Detroit Lions (13-2), the San Francisco 49ers (6-9) are monitoring 15 players on their injury report. The Lions' (13-2) injury report currently has five players ...

Somehow, the San Francisco 49ers playoff hopes are alive. It may feel absurd to believe that with a 6-8 record, the 49ers are clinging to a less than one percent chance to squeak in as the seventh ...