In children who have achondroplasia, there is a mutation in their DNA that disrupts signaling between certain proteins in the body. There are two different signaling pathways in your body ...

Achondroplasia is a rare genetic disorder of bone growth that causes short-limbed dwarfism. It occurs due to mutations in a single gene called the FGFR3.

What happens when good genes go bad? What kinds of mutations create "lethal genes," and how are they passed on? Lethal genes can be recessive, as in the aforementioned mouse experiments.