Objectives Coagulation changes associated with COVID-19 suggest the presence of a hypercoagulable state with pulmonary microthrombosis and thromboembolic complications. We assessed the dynamic ...

Table 1. Table 1. Common Causes of Disseminated Intravascular Coagulation in Patients With Cancer Infections : Gram-negative bacteria. Meningococcus, Pseudomonas, Salmonella, Haemophilus ...

Tumors may also release necrotic tissue or tissue enzymes into the general circulation, thereby activating the coagulation cascade. DIC may also be related to blood transfusions, ...

Heparan sulfate (HS), dermatan sulfate (DS), and heparin are natural glycosaminoglycans (GAG), which are linear polysaccharides, heterogeneous in both sequence and length. 1 GAGs carry out many ...

Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins. A single ...

For inhibition of thrombin, heparin must bind to both the coagulation enzyme and AT, but binding to the enzyme is less important for inhibition of activated factor X (factor Xa; Figure 3). 21 ...

Interference with coagulation cascade may be a promising nephroprotective strategy against chemical nephrotoxicity. Introduction. Acute tubular necrosis (ATN) is one of acute renal failure (ARF) ...

Selective prodrug activation at tumor sites through noninvasive external stimuli represents a promising strategy in enhancing the therapeutic index. Here, we report a p-azidobenzyloxycarbonyl ...

To get to the site of inflammation, leukocytes must first adhere to and traverse the blood-vessel wall, events that occur in a cascade-like manner. But what are the exact steps in this cascade and ...