In fact, reactions of alkylating agents with nucleosomal DNA typically mirror those seen with naked DNA, showing very similar sequence preferences and only modestly (2- to 3-fold) decreased adduct ...

While alkylating agents can be highly effective in disrupting cancer cell growth, these drugs also pose a potential risk. They can harm the cells in bone marrow, which produces red blood cells. In ...

Alkylating agents do this by attaching to the cell’s DNA and stopping the cells from multiplying. The drugs target rapidly dividing cancer cells, slow down cell growth, and kill them in a ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

Chemotherapeutic DNA alkylating agents are common weapons employed to fight both pediatric and adult cancers. In addition to cancerous cells, nontarget tissues are subjected to the cytotoxicity of ...

Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

The sensor can detect DNA-alkylating agents, a class that includes cisplatin, and oxidizing agents such as hydrogen peroxide and hydroxyl radicals. Using the sensors, researchers can monitor ...

Published today (1 July 2025) in Nature Genetics, the researchers show that many but not all chemotherapy agents cause ...

Alkylating agents. These agents damage DNA and prevent mitosis. They are used to treat leukemia, lymphomas, multiple myeloma, sarcoma and lung, breast, and ovarian cancer.

1. Alkylating Agents. These drugs interfere with the DNA inside cells, preventing them from multiplying. DNA is the genetic material in cells that guides their growth and function.

It is apparent that uracil mustard is an effective alkylating agent for oral use, administered as a large dose in a few days (0.5 to 0.8 mg. per kilogram of body weight over three days) as ...

MMS is a DNA alkylating agent mechanistically similar to several agents commonly used in cancer chemotherapy. Alkylating agents “are known to induce replication stress, potentially mimicking the ...