or an alkylating agent, that causes mutations in DNA. Those mutant cells were then screened for sensitivity to DNA damaging agents. Many mutant cells were identified, and careful genetic studies ...
use in GBM lines in conjunction with the first-line DNA alkylating agent, Temozolomide (TMZ), and secondline DNA Toposiomase-1 inhibitor, Topotecan (TPT). This analysis has enabled a new level of ...
Melphalan is an alkylating agent with cytotoxic action that appears to be related to the extent of its interstrand cross-linking with DNA, probably by binding at the N7 position of guanine.
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