Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues. Researchers from the Wellcome Sanger Institute, the University of Cambridge, ...

OBI's pipeline also includes the first-in-class AKR1C3-targeted small-molecule prodrug OBI-3424, which selectively releases a potent DNA-alkylating antitumor agent in the presence of the aldo-keto ...

Joshua K. Sabari, MD, describes the mechanism of action of lurbinectedin as a synthetic alkaloid that binds to guanine residues in the minor groove of DNA, forming adducts that disrupt DNA repair ...

DNMTs sensitize cells to alkylation damage. Our previous work demonstrated that DNMTs induce alkylation damage in the form of 3mC into genomic DNA(Rošić et al., 2018).To investigate the effect of this ...

NEO212 combines the DNA alkylating agent Temozolomide (TMZ) with NEO100 ™, NeOnc’s leading drug candidate that is a proprietary, highly purified formulation of Perillyl Alcohol (POH). NEO212 was ...

In theory, if the activity of DNA alkylating agents exceeds the synthetic capacity of the MGMT enzyme, the enzyme becomes depleted, allowing the alkylating agent to maintain its therapeutic function.

Alkylating agents do this by attaching to the cell’s DNA and stopping the cells from multiplying. The drugs target rapidly dividing cancer cells, slow down cell growth, and kill them in a ...

Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic ...